Friday, January 25, 2013

What We're Reading: Is investing in Africa a good bet? | ONE

Huffington Post: Germany Davos Announcement: Country Donates 1 Billion Euros To The Global Fund ? Germany?s Minister for Economic Cooperation and Development, Dirk Niebel, announced on Thursday at the World Economic Forum in Davos that it will increase its contribution to The Global Fund to 1 billion Euros. Germany had already committed 400 million Euros over the past two years, and the announcement extends the country?s commitment to another 600 million Euros over the next three years. ?We need to continue to devote hard work and determined efforts to halting the spread of HIV, malaria and other infectious diseases,? said Niebel. (Lance Gould)

Guardian: Opinion: To stop hunger, it?s not enough to change policy; we must challenge power ? The If campaign proposes policy options aimed at ending hunger: ?more aid, stopping companies dodging taxes, stopping land grabbing for biofuels and other crops, and forcing governments and companies to be more transparent about their investments in developing countries.? While all important goals, in order to end hunger and poverty we need to tackle their root causes. (Deborah Doane)

VOA: Is Investing in Africa a Good Bet? ? Many sub-Saharan countries have had sustained economic growth despite the global recession, but ?conflict, political instability and weather extremes? still deter some investors. At the World Economic Forum in Davos, African leaders discussed strategies for making the continent more attractive to investors. South African President Jacob Zuma explained that African leaders are coming together to ?grow out infrastructure; to grow our intra-trade . . . [and] to integrate the five economic regions in the continent.? (Joe DeCapua)

Bloomberg: Africa Infrastructure Deficit Widening, SABMiller Chairman Says ? The lack of basic infrastructure in Africa is hampering investments by companies, and according to the World Bank, Africa needs $93 billion per year over a decade to improve infrastructure, with ?almost half that required to boost power supply.? Despite the fact that the economies of sub-Saharan Africa countries will expand 5.3 percent this year, the infrastructure gap is still significant. (Maram Mazen)

Washington Post: Fake drugs flood East African markets ? Government officials and international aid agencies have long encouraged the sick to place their trust in modern medicine. Recently, however, the influx of fake pharmaceuticals from Asia into Uganda and other African nations have ?pushed patients back to traditional healers.? In cities like Kampala, Uganda, waiting in long lines at clinics takes vulnerable time and top-end malaria cures are expensive. Because of this, when a malarial fever strikes, many people search for medicine in neighborhood drugstores, where the fakes are frequently found. (Kathleen McLaughlin)

Source: http://www.one.org/us/2013/01/24/what-were-reading-is-investing-in-africa-a-good-bet/

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Wednesday, January 23, 2013

WPMU DEV Review - A Membership with Vast Potential plus ...

As we are advancing through a modern technological era there is a greater demand for effective expression through a written platform. As users of technology, whether experienced or simply new, we always strive for a means of such expression ? to get a perspective across, to provide facts: to change the thoughts of those who are interested.

With these demands in mind, many internet users are seeking a platform for this expression and modern blogging websites have become fundamental to satisfying these needs ? WordPress, as an example, has garnished it's name with a firm reputation for ease of use. This, to some extent, is very true indeed. Though certain aspects plague what could be a completely efficient tool for website publishing.

WPMU DEV Review - A Membership with Vast Potential plus Giveaways!

Though the topic for this piece revolves around the possibility of expanding the horizons of WordPress, largely through the use of modernised plugins and arrays of themes for designing. The question has arisen countless times and answered equally as much, 'Is it too good to be true?'. The answer is no.

Can a WPMU-Dev Membership Assist Your Site?

So we take on WPMU Dev: and the membership, which seemingly gives you endless freedom of customisation and expression ? for a price. So are these claims met to a satisfactory level? Or will you, as the potential customer, be left in the dark and thus questioning the reliability of this membership. To answer this question, perhaps we should delve into the benefits provided by gaining the membership ? and from there we can collect the positives and the negatives, and help manifest a conclusion.

The Fundamental Features ? Are They Worth It?

So what is offered exactly well let's take a quick peek:

With a membership on WPMU Dev, you will gain 140+ plugins for your WordPress site. You will gain access to 160+ themes, with the added support for those with more experience.

These two points are, largely, the fundamental benefits within the package, along with the added support granted through live Q&A and manuals. So what does this mean for you as a user of WordPress?

You will be given a vast amount of liberty in choosing the appearance of your site with the collection of themes available, while also being able to enhance the functionality of your website through the use of plugins (some notable plugins include 'The new blog templates' and 'Custom press', amongst many more). In contrast, if you are unsure about certain aspects regarding the membership, or WordPress in general, you have firm access to manual support and live help with a professional. This, for newcomers in particular, is immensely important and should naturally entice.

WPMU DEV Support

In regards to usability, there is a negative factor, which potential customers should consider. The choice of themes and plugins, though carrying the potential of customisation for a web developer, are not so easily accessible for a beginner. Many of the plugins, though quite helpful by themselves, lack the potential of customisation for those who are not acquainted with web developing or those who are not knowledgeable in coding a website or designing.

Thus this particular limitation is largely a result of technological barriers, which, therefore, may cause difficulties for certain users who are not 'tech' enthusiasts. Users who carry knowledge in web development may therefore be better suited to using the plugins provided by WPMU Dev, due to having experience and knowledge.

Another element, which at this stage may dishearten potential customers, is the fact that the amount of themes is limited. Due to this, many websites may carry a similar appearance to one another. This is largely a result of lack of knowledge regarding customisation options and methods. So it may be said quite frankly ? the WPMU Dev membership has the potential to appease and satisfy newcomers into the world of website creation, though users who have no particular inclination towards web development, may not be able to utilise the features of the membership to the full extent.

Despite these technological limitations, this particular membership carries a large amount of potential for business' and website owners alike. Within the membership there are many notable plugins, which provide simplicity for managing a business online. For example, the use of specific plugins such as 'Appointments+': a plugin, which will categorise and manage appointments ? can essentially be pivotal to the success of a modern business. This plugin, amidst a category of others, is a testament to providing simplicity for the user.

It is relevant to note that there is in fact future potential for this membership in regards to the implementation of unique plugins. WordPress have brought forward an interesting point regarding the prematurity of the WMBU Dev membership: they have openly affirmed the fact that future updates will be released on a continual basis which may bring forth some excitement. This, in some regard, gives extra value to the membership itself due to the fact that more plugins and extra themes will be released and perhaps even new, unique features.

Notable Plugins within the Membership

One aspect that the team at WordPress perfected was the broad choice of plugins made available for the user: each being effective and unique to the other. So which particular plugins are quintessential to a website owner?

WPMU DEV Plugins

The Appointments+ plugin is incredibly helpful for organising and managing appointments while providing simplicity for both customers of a business and owners.

The WPMU Dev's snapshot plugin is equally as effective. This plugin essentially gives the user piece of mind, knowing that your database is completely safe and stored away if the worst was to happen.

Pricing ? Does It Comply with Your Wallet?

Within the phase of the new year, WordPress is propelling its own price cuts for the WPMU Dev membership. The pricing, for the time being, has been lowered quite significantly:

Typically, the pricing for a full membership costs $79. This price, quite fairly, may be viewed as over-priced considering the prematurity of the features.

WPMU DEV Pricing

At the current stage, WordPress are providing an offer for new users, which is expressed as being for a 'limited time'. The total price is slashed down to $39.50: thus much more lenient on the wallet.

The price is therefore acceptable and doesn't place a heavy strain on a potential website owner who, most probably, is already gathering an income through either business or advertising.

In Summary

Overall, the WPMU Dev membership carries its worth through the broad category of options for themes and plugins with the added support of live Q&A. WordPress has solidified its reputation for ease of use and has marked a phase of originality with the innovative plugins previously mentioned.

The primary negative aspect, which should be emphasised however, is the technological barrier, which may conflict with plugin customisation for a beginner to web development ? certain features of WPMU Dev rely upon the web developmental knowledge of the user.

For a newcomer to basic website creation: the WPMU Dev membership will more than satisfy in creating and editing a website layout and structure. The focus on simplicity is a fundamental benefit to any website owner, and WordPress does not fail on this front.

Giveaways

We are excited to partner with WPMU DEV and give away 3 free memberships for our esteemed readers. Read on to find out how you can become one of the winners.

The Prizes

3 X 1 year full memberships total worth $1542 ($514 value per membership)

How to Win?

Please follow the below simple steps in order to be eligible for the contest.

  • Submit a comment to this post telling us how you can make use of WPMU Dev.
  • Follow @wpmuorg and @onextrapixel on Twitter and include the tweeted link together in your comment.
  • Like WPMU DEV and onextrapixel on Facebook.
  • You can also follow WPMU DEV on Google+ to double your chance on winning.

This giveaway ends on 28th January 2013. Please use a valid email address when filling out the comment form. Please comment only once.

The winners will be selected at random, contacted by email within 3 business days after the contest is over and announced in this article.

Good luck, everyone!

Source: http://www.onextrapixel.com/2013/01/22/wpmu-dev-review-a-membership-with-vast-potential-plus-giveaways/

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Tuesday, January 22, 2013

New way to kill lymphoma without chemotherapy

Tuesday, January 22, 2013

How do you annihilate lymphoma without using any drugs?

Starve it to death by depriving it of what appears to be a favorite food: HDL cholesterol.

Northwestern Medicine? researchers discovered this with a new nanoparticle that acts like a secret double agent. It appears to the cancerous lymphoma cell like a preferred meal -- natural HDL. But when the particle engages the cell, it actually plugs it up and blocks cholesterol from entering. Deprived of an essential nutrient, the cell eventually dies.

A new study by C. Shad Thaxton, M.D., and Leo I. Gordon, M.D. shows that synthetic HDL nanoparticles killed B-cell lymphoma, the most common form of the disease, in cultured human cells, and inhibited human B-cell lymphoma tumor growth in mice.

The paper will be published Jan. 21 in the journal Proceedings of the National Academy of Sciences.

"This has the potential to eventually become a nontoxic treatment for B-cell lymphoma which does not involve chemotherapy," said Gordon, a co-corresponding author with Thaxton on the paper. "It's an exciting preliminary finding."

Gordon is a professor of medicine in hematology/oncology and Thaxton is an assistant professor of urology, both at Northwestern University Feinberg School of Medicine.

Gordon also is co-director of the hematologic malignancy program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and a physician at Northwestern Memorial Hospital. Thaxton is also a member of the Lurie Cancer Center.

Lymphoma Gobbles HDL Cholesterol

Recent studies have shown that B-cell lymphoma is dependent on the uptake of natural HDL -- short for high-density lipoprotein -- from which it derives fat content, such as cholesterol.

The nanoparticle -- originally developed by Thaxton as a possible therapy for heart disease -- closely mimics the size, shape and surface chemistry of natural HDL particles. But it has one key difference: a five nanometer gold particle at its core. Thus, when the nanoparticle is incubated with human B-cell lymphoma cells or used to treat a mouse with the human tumor, it socks lymphoma with a double whammy. After it attaches to the lymphoma cell, the gold particle's spongy surface sucks out its cholesterol while the gold core prevents the cell from absorbing more cholesterol typically carried in the core of natural HDL particles.

The lymphoma research showed Thaxton that the HDL nanoparticle had more than one trick up its golden sleeve.

"At first I was heavily focused on developing nanoparticles that could remove cholesterol from cells, especially those involved in heart disease," Thaxton said. "The lymphoma work has broadened this focus to how the HDL nanoparticles impact both the removal and uptake of cholesterol by cells. We discovered the particles are multi-taskers."

The Northwestern study also showed that natural HDL did not kill the cells or inhibit tumor growth. The nanoparticle was essential to starve the lymphoma cell.

Detour From Heart Disease to Cancer Killer

After developing the HDL nanoparticle, Thaxton gave a lecture in 2010 to Feinberg faculty. Gordon was in the audience. He knew that patients with advanced forms of B-cell lymphoma sometimes have dropping levels of cholesterol. A long-time lymphoma researcher and oncologist, Gordon was looking for new methods to deliver drugs to patients. He contacted Thaxton and they began to collaborate.

They tested the HDL nanoparticle alone and the HDL nanoparticle transporting cancer drugs. Surprisingly, the nanoparticle without drugs was just as effective at killing the B-cell lymphoma cells.

"We thought, 'That's odd. Why don't we need the drug?'" Gordon recalled.

That's when the scientists began delving into the mechanism by which the HDL nanoparticles were sticking to the HDL receptors on the lymphoma cell and manipulating cholesterol transport. In addition, patient samples analyzed by collaborators at Duke University for the study showed that lymphoma cells in patients had an overproduction of these HDL receptors compared to normal lymphocytes.

B-cell Lymphoma Most Common Lymphoma

The National Cancer Institutes reports that in 2012 there were about 70,000 new cases of non-Hodgkin lymphoma in the U.S. with nearly 19,000 deaths. About 90 percent of those new cases were B-cell lymphoma. Non-Hodgkin lymphoma is a cancer that starts in cells called lymphocytes, which are part of the body's immune system.

Why a Heart of Gold?

"Gold has a good track record of being compatible with biologic systems," Thaxton said.

Thaxton and Gordon are encouraged by their early data showing that the HDL nanoparticles do not appear toxic to other human cells normally targeted by HDLs, normal human lymphocytes or to mice. Also, because gold nanoparticles can be made in a discreet size and shape, they are excellent scaffolds for creating synthetic HDLs that closely mimic those found in nature.

"Like every new drug candidate, the HDL nanoparticle will need to undergo further testing," Thaxton noted.

###

Northwestern University: http://www.northwestern.edu

Thanks to Northwestern University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 26 time(s).

Source: http://www.labspaces.net/126383/New_way_to_kill_lymphoma_without_chemotherapy

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LA church leaders shielded molesters, records show

Damian Dovarganes / AP

The entrance to the Cathedral of Our Lady of the Angels, headquarters for Roman Catholic Archdiocese of Los Angeles, is seen Jan. 21.

By Gillian Flaccus, The Associated Press

Retired Cardinal Roger Mahony and other top Roman Catholic Archdiocese of Los Angeles officials maneuvered behind the scenes to shield molester priests, provide damage control for the church and keep parishioners in the dark, according to church personnel files.

The confidential records filed in a lawsuit against the archdiocese disclose how the church handled abuse allegations for decades and also reveal dissent from a top Mahony aide who criticized his superiors for covering up allegations of abuse rather than protecting children.

Notes inked by Mahony demonstrate he was disturbed about abuse and sent problem priests for treatment, but there also were lengthy delays or oversights in some cases. Mahony received psychological reports on some priests that mentioned the possibility of many other victims, for example, but there is no indication that he or other church leaders investigated further.

"This is all intolerable and unacceptable to me," Mahony wrote in 1991 on a file of the Rev. Lynn Caffoe, a priest suspected of locking boys in his room, videotaping their crotches and running up a $100 phone sex bill while with a boy. Caffoe was sent for therapy and removed from ministry, but Mahony didn't move to defrock him until 2004, a decade after the archdiocese lost track of him.

"He is a fugitive from justice," Mahony wrote to the Vatican's Cardinal Joseph Ratzinger, who is now Pope Benedict XVI. "A check of the Social Security index discloses no report of his demise, so presumably he is alive somewhere."

Caffoe died in 2009, six years after a newspaper reporter found him working at a homeless mission two blocks from a Salinas elementary school.

Mahony was out of town but issued a statement Monday apologizing for his mistakes and saying he had been "naive" about the lasting impacts of abuse. He has since met with 90 abuse victims privately and keeps an index card with each victim's name in his private chapel, where he prays for them daily, he said. The card also includes the name of the molesting priest "lest I forget that real priests created this appalling harm."

"It remains my daily and fervent prayer that God's grace will flood the heart and soul of each victim, and that their life journey continues forward with ever greater healing," Mahony wrote. "I am sorry."

The apology stands in contrast to letters Mahony was writing to accused priests more than two decades ago.

In 1987, he wrote to the Rev. Michael Wempe ? who would ultimately admit to abusing 13 boys ? while the priest was undergoing in-patient therapy at a New Mexico treatment center.

"Each of you there at Jemez Springs is very much in my prayers and I call you to mind each day during my celebration of the Eucharist," Mahony wrote to the priest, adding that he supported him in the experience.

The church's sex abuse policy was evolving and Mahony inherited some of the worst cases from his predecessor when he took over in 1985, J. Michael Hennigan, an archdiocese attorney, said in a separate series of emails. Priests were sent out of state for psychological treatment because they revealed more when their therapists were not required to report child abuse to law enforcement, as they were in California, he said.

At the time, clergy were not mandated sex abuse reporters and the church let the victims' families decide whether to contact police, he added.

In at least one case, a priest victimized the children of illegal immigrants and threatened to have them deported if they told, the files show.

The files are attached to a motion seeking punitive damages in a case involving a Mexican priest sent to Los Angeles in 1987 after he was brutally beaten in his parish south of Mexico City.

When parents complained the Rev. Nicholas Aguilar Rivera molested in LA, church officials told the priest but waited two days to call police ? allowing him to flee to Mexico, court papers allege. At least 26 children told police they were abused during his 10 months in Los Angeles. The now-defrocked priest is believed to be in Mexico and remains a fugitive.

The personnel files of 13 other clerics were attached to the motion to show a cover-up pattern, said attorney Anthony De Marco, who represents the 35-year-old plaintiff. In one instance, a memo to Mahony discusses sending a cleric to a therapist who also is an attorney so any incriminating evidence is protected from authorities by lawyer-client privilege. In another instance, archdiocese officials paid a secret salary to a priest exiled to the Philippines after he and six other clerics were accused of having sex with a teen and impregnating her.

The exhibits offer a glimpse at some 30,000 pages to be made public as part of a record-setting $660 million settlement. The archdiocese agreed to give the files to more than 500 victims of priest abuse in 2007, but a lawyer for about 30 of the priests fought to keep records sealed. A judge recently ordered the church to release them without blacking out the names of church higher-ups after The Associated Press and the Los Angeles Times intervened.

They echo similar releases from other dioceses nationwide that have shown how church leaders for decades shuffled problem priests from parish to parish, covered up reports of abuse and didn't contact law enforcement. Top church officials in Missouri and Pennsylvania were criminally convicted last year for their roles in covering up abuse, more than a decade after the clergy sex abuse scandal began to unfold in Boston.

Mahony, who retired in 2011 after 26 years at the helm of the 4.3-million person archdiocese, has been particularly hounded by the case of the Rev. Michael Baker, who was sentenced to prison in 2007 for molestation ? two decades after the priest confessed his abuse to Mahony.

Mahony noted the "extremely grave and serious situation" when he sent Baker for psychological treatment after the priest told him in 1986 that he had molested two brothers over seven years.

Baker returned to ministry the next year with a doctor's recommendation that he be defrocked immediately if he spent any time with minors. Despite several documented instances of being alone with boys, the priest wasn't removed from ministry until 2000. Around the same time, the church learned he was conducting baptisms without permission.

Church officials discussed announcing Baker's abuse in churches where he had worked, but Mahony rejected the idea.

"We could open up another firestorm ? and it takes us years to recover from those," Mahony wrote in an Oct. 6, 2000, memo. "Is there no alternative to public announcements at all the Masses in 15 parishes??? Wow ? that really scares the daylights out of me!!"

The aide, Msgr. Richard Loomis, noted his dismay over the matter when he retired in 2001 as vicar for clergy, the top church official who handled priestly discipline. In a memo to his successor, Loomis said Baker's attorney disclosed the priest had at least 10 other victims.

"We've stepped back 20 years and are being driven by the need to cover-up and to keep the presbyteriate & public happily ignorant rather than the need to protect children," Loomis wrote.

"The only other option is to sit and wait until another victim comes forward. Then someone else will end up owning the archdiocese of Los Angeles. The liability issues involved aside, I think that course of complete (in)action would be immoral and unethical."

Mahony preferred targeted warnings at schools and youth groups rather than a warning read at Masses, Hennigan said. Parish announcements were made two years later.

Baker, who was paroled in 2011, is alleged to have molested 20 children in his 26-year career. He could not be reached for comment.

The files also show Mahony corresponded with abusive priests while they underwent treatment out of state and worked to keep them out of California to avoid criminal and civil trouble.

One case involved the Msgr. Peter Garcia, a molester whom Mahony's predecessor sent for treatment in New Mexico. Mahony kept Garcia there after a lawyer warned in 1986 that the archdiocese could face "severe civil liability" if he returned and reoffended. Garcia had admitted raping an 11-year-old boy and later told a psychologist he molested 15 to 17 young boys.

"If Monsignor Garcia were to reappear here within the archdiocese, we might very well have some type of legal action filed in both the criminal and civil sectors," Mahony wrote to the director of Garcia's New Mexico treatment program.

Mahony then sent Garcia to another treatment center, but Garcia returned to LA in 1988 after being removed from ministry. He then contacted a victim's mother and asked to spend time with her younger son, according to a letter in the file.

Mahony moved to defrock him in 1989, and Garcia died a decade later.

? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://usnews.nbcnews.com/_news/2013/01/22/16641582-la-church-leaders-shielded-molester-priests-records-show?lite

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Monday, January 21, 2013

Benitez confirms new contract for Cole

Associated Press Sports

updated 11:34 a.m. ET Jan. 20, 2013

LONDON (AP) -Chelsea manager Rafa Benitez has confirmed Ashley Cole has reached an agreement with the club over a new contract, but sidestepped any talk about the future of Frank Lampard.

The 32-year-old Cole, one of the world's top left backs, is expected to sign his deal Monday and Benitez says "I am really pleased - the paperwork has to be done but the agreement is there."

Lampard appears to be on his way out of Stamford Bridge, however, with the club yet to offer him a new contract.

Speaking after Sunday's 2-1 win over Arsenal, in which Lampard scored a penalty, Benitez said the 34-year-old midfielder is "doing a great job ... he is playing well" but stressed "it is not my decision" to extend his stay at the club.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Dempsey saves the day for Spurs

Clint Dempsey scored a second crucial goal of the season for Tottenham against Manchester United on Sunday, striking deep into stoppage time to secure a 1-1 draw against the Premier League leaders.

Who had best weekend, Jozy or Clint?

PST: Jozy Altidore seemed to have a stranglehold on best weekend for a Yank abroad,?but what about Clint Dempsey?s day at snowy White Hart Lane?

Source: http://nbcsports.msnbc.com/id/50519913/ns/sports-soccer/

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Samsung?s 8-Inch Galaxy Note Tablet Is Reportedly Set For Its February MWC Debut

galnote103Well, it certainly seems like a good time to be on the market for an Android tablet -- Sony has just announced its attractive new Tablet Z, and it seems that Samsung really does have another Note tab up its proverbial sleeves. According to Korean news outlet iNews 24, Samsung Mobile chief JK Shin has confirmed that the company's rumored 8-inch Galaxy Note tablet will indeed making an appearance at Mobile World Congress in Barcelona.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/pFBZpIjgl64/

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Photos: Virginia Inaugural Ball

Patch:

This year's Virginia Inaugural Ball was Sunday night at the Westin Arlington Gateway.

Read the whole story at Patch

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Source: http://www.huffingtonpost.com/2013/01/20/photos-virginia-inaugural_n_2517876.html

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